Journal of Innovative Research in Engineering Sciences



A review on Helicobacter Pylori and its antibiotic resistance

Melika Sahebjamei

Helicobacter Pylori (H. Pylori) has infected about 50% of the world population. The annual incidence of Helicobacter pylori infection is significant: 4-15% and 0.5% in the developing and developed countries, respectively. This study is thus aimed to review H. pylori and its relationship with antibiotic resistance.

Research Methods:

In this research, Google Scholar, Embase, (SID), ISI Scopus, and Pubmed research databases were fully explored to obtain different articles in this field. Here, 48 articles conducted in Iran and foreign countries from 1995 to 2018 were reviewed; among which, 35 papers were investigated while the rest were excluded. This research is aimed to survey the antibiotic resistance of H. pylori.


Studies have revealed quit high levels of resistance to metronidazole and clarithromycin (two well-known therapeutic antibiotics). Moreover, different studies reported different antibiotic susceptibility of H. pylori which can be assigned to various factors such as improper choice of antibiotics, excessive use of antibiotics, lack of sufficient care on the duration of treatment, inability of all laboratories to culture this bacterium and its subsequent antibiogram testing and most importantly non-compliance with standard conditions, especially in different stages of antibiogram testing. Given the various statistics on antibiotic resistance, it is necessary to perform antibiotic tests to provide better treatment for the patients.

Published on the web: 09, Jun, 2020
Received : 17, May, 2020
Submitting : 12, February, 2020
Keyword:1- infection
Keyword:2- antibiotic resistance
Keyword:3- Helicobacter Pylori

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